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Publications

  1. Lobitz, A.; Steuber, A.; Chen, M.; Afshar Mohajer, M.; Feng, R.; Barry, M.; Harris, B.; Zou, M.; Jia, S.; Guo, L. Fluorous Modification of Commercial Resins for Ultrashort and Short Chain PFAS Removal. ACS EST Water 2025, 5 (11), 6633–6643. First published here: [ChemRxiv]
  2. Xiao, T.; He, D.; Liu, D.; Jia, S.; Chen, Q.; Silverman, D.; Maitra, N.; Huang, A.Y.; Pezacki, A.; Nguyen, T.T.; Rao, G.; Tillage, R.; Deng, K.; Weinshenker, D.; Britt, R.D.; Kelly, M.J.S.; Dan, Y.; Chang, C.J. RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity. Molecular Cell. 2025, 85 (18), 3443-3459.e11. First published here: [Sneak Peek]
  3. Lobitz, A.; Steuber, A.; Jia, S.; Guo, L. Harnessing Fluorine Chemistry: Strategies for PFAS Removal and Enrichment. ChemPlusChem 2025, 90 (7), e202400784.
  4. Guo, L.; Yang, M.; Dong, B.; Lewman, S.; Van Horn, A.; Jia, S. Engineering Central Substitutions in Heptamethine Dyes for Improved Fluorophore Performance. JACS Au 2024, 4 (8), 3007–3017. First published here: [ChemRxiv].
  5. Song, L.; Nguyen, V.; Xie, J.; Jia, S.; Chang, C.J.; Uchio, E.; Zi, X. ATPase Copper Transporting Beta (ATP7B) is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer. Mol. Cancer Ther. 2024, 23 (6), 854–863.

Before 2024

  1. Jia, S.; Lin, E.; Mobley, E.B.; Lim, I.; Guo, L.; Kallepu,S.; Low, P.S.; Sletten, E.M. Water Soluble Chromenylium Dyes for Shortwave Infrared Imaging in Mice. Chem 2023, 9 (12), 3648–3665. First published here: [ChemRxiv].
  2. Jia, S.; Chang, C. J. Activity-Based Sensing: Principles and Probes for Selective Bioimaging. In Fluorescent Chemosensors; Wu, L., Sedgwick, A. C., He, X.-P., James, T. D.; The Royal Society of Chemistry, 2023, pp 17–39.
  3. Lim, I.; Lin, E.; Garcia, J.; Jia, S.; Sommerhalter, R.; Ghosh, S.; Gladysz, J.; Sletten, E.M. Shortwave Infrared Fluorofluorophores for Multicolor in Vivo Imaging. 2022, 62 (6), e202215200. First published here: [ChemRxiv].
  4. Kataki-Anastasakou, A.; Jia, S.; Axtell, J. C.; Sletten, E. M. A Fluorescent Unnatural Mannosamine Derivative with Enhanced Emission Upon Complexation with Cucurbit[7]Uril. Isr. J. Chem. 2022, e202200069.
  5. Scrivner, O.; Dao, L.; Newell-Rogers, M. K.; Shahandeh, B.; Meyskens, F. L.; Kozawa, S. K.; Liu-Smith, F.; Plascencia-Villa, G.; José-Yacamán, M.; Jia, S.; Chang, C.J. The Ionophore Thiomaltol Induces Rapid Lysosomal Accumulation of Copper and Apoptosis in Melanoma. Metallomics 2022, 14 (1), mfab074.
  6. Jia, S.; Sletten, E.M. Spatiotemporal Control of Biology: Synthetic Photochemistry Toolbox with Far-Red and Near Infrared Light. ACS. Chem. Biol. 2021, 17 (12), 3255–3269.
  7. Jia, S.; Chang, C. J. A Microtubule-Localizing Activity-Based Sensing Fluorescent Probe for Imaging Hydrogen Peroxide in Living Cells. Bioorg. Med. Chem. Lett. 2021, 48, 128252.
  8. Friedman, H.C.; Cosco, E.D.; Atallah, T.L.; Jia, S.; Sletten, E.M.; Caram, J.R. Establishing Design Principles for Emissive Organic SWIR Chromophores from Energy Gap Laws. Chem 2021, 7 (12), 3359–3376. First published here: [ChemRxiv].
  9. Kim, J.-H.; Matsubara, T.; Lee, J.; Fenollar-Ferrer, C.; Han, K.; Kim, D.; Jia, S.; Chang, C. J.; Yang, H.; Nagano, T.; Krausz, K. W.; Yim, S.-H.; Gonzalez, F. J. Lysosomal SLC46A3 Modulates Hepatic Cytosolic Copper Homeostasis. Nat. Commun. 2021, 12 (1), 290.
  10. Lo, M. N.; Damon, L. J.; Wei Tay, J.; Jia, S.; Palmer, A. E. Single Cell Analysis Reveals Multiple Requirements for Zinc in the Mammalian Cell Cycle. eLife 2020, 9, e51107.
  11. Liao, Y.; Zhao, J.; Bulek, K.; Tang, F.; Chen, X.; Cai, G.; Jia, S.; Fox, P. L.; Huang, E.; Pizarro, T. T.; Kalady, M. F.; Jackson, M. W.; Bao, S.; Sen, G. C.; Stark, G. R.; Chang, C. J.; Li, X. Inflammation Mobilizes Copper Metabolism to Promote Colon Tumorigenesis via an IL-17-STEAP4-XIAP Axis. Nat. Commun. 2020, 11 (1), 1–15.
  12. Guo, L.; Jia, S.; Diercks, C. S.; Yang, X.; Alshmimri, S. A.; Yaghi, O. M. Amidation, Esterification, and Thioesterification of a Carboxyl-Functionalized Covalent Organic Framework. Angew. Chem. Int. Ed. 2020, 59 (5), 2023–2027.
  13. Iovan, D. A.†; Jia, S.†; Chang, C. J. Inorganic Chemistry Approaches to Activity-Based Sensing: From Metal Sensors to Bioorthogonal Metal Chemistry. Inorg. Chem. 2019, 58 (20), 13546–13560.
  14. Jia, S.; He, D.; Chang, C. J. Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation. J. Am. Chem. Soc. 2019, 141 (18), 7294–7301. First published here: [ChemRxiv].
  15. Christian, A. H.; Jia, S.; Cao, W.; Zhang, P.; Meza, A. T.; Sigman, M. S.; Chang, C. J.; Toste, F. D. A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation. J. Am. Chem. Soc. 2019, 141 (32), 12657–12662. First published here: [ChemRxiv].
  16. Jia, S.†; Ramos-Torres, K. M.†; Kolemen, S.; Ackerman, C. M.; Chang, C. J. Tuning the Color Palette of Fluorescent Copper Sensors through Systematic Heteroatom Substitution at Rhodol Cores. ACS Chem. Biol. 2018, 13 (7), 1844–1852.
  17. Xiao, T.; Ackerman, C. M.; Carroll, E. C.; Jia, S.; Hoagland, A.; Chan, J.; Thai, B.; Liu, C. S.; Isacoff, E. Y.; Chang, C. J. Copper Regulates Rest-Activity Cycles through the Locus Coeruleus-Norepinephrine System. Nat. Chem. Biol. 2018, 14 (7), 655–663.
  18. Su, T. A.; Shihadih, D. S.; Cao, W.; Detomasi, T. C.; Heffern, M. C.; Jia, S.; Stahl, A.; Chang, C. J. A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals. J. Am. Chem. Soc. 2018, 140 (42), 13764–13774.
  19. Lin, S.†; Yang, X.†; Jia, S.; Weeks, A. M.; Hornsby, M.; Lee, P. S.; Nichiporuk, R. V.; Iavarone, A. T.; Wells, J. A.; Toste, F. D.; Chang, C. J. Redox-Based Reagents for Chemoselective Methionine Bioconjugation. Science 2017, 355 (6325), 597–602.
  20. Chun, H.; Sharma, A. K.; Lee, J.; Chan, J.; Jia, S.; Kim, B.-E. The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis Elegans. J. Biol. Chem. 2017, 292 (1), 1–14.
  21. Krishnamoorthy, L.†; Cotruvo, J. A.†; Chan, J.; Kaluarachchi, H.; Muchenditsi, A.; Pendyala, V. S.; Jia, S.; Aron, A. T.; Ackerman, C. M.; Wal, M. N. V.; Guan, T.; Smaga, L. P.; Farhi, S. L.; New, E. J.; Lutsenko, S.; Chang, C. J. Copper Regulates Cyclic-AMP-Dependent Lipolysis. Nat. Chem. Biol. 2016, 12 (8), 586–592.
  22. Li, J.†; Jia, S.†; Chen, P. R. Diels-Alder Reaction–Triggered Bioorthogonal Protein Decaging in Living Cells. Nat. Chem. Biol. 2014, 10 (12), 1003–1005.
  23. Li, J.; Yu, J.; Zhao, J.; Wang, J.; Zheng, S.; Lin, S.; Chen, L.; Yang, M.; Jia, S.; Zhang, X.; Chen, P. R. Palladium-Triggered Deprotection Chemistry for Protein Activation in Living Cells. Nat. Chem. 2014, 6 (4), 352–361.
  24. Li, J.; Lin, S.; Wang, J.; Jia, S.; Yang, M.; Hao, Z.; Zhang, X.; Chen, P. R. Ligand-Free Palladium-Mediated Site-Specific Protein Labeling Inside Gram-Negative Bacterial Pathogens. J. Am. Chem. Soc. 2013, 135 (19), 7330–7338.

† denotes co-first authorship.